| Short Description : | Rabbit polyclonal HEXIM2 (147-286) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HEXIM2 |
| Gene ID: | 124790 |
| Uniprot ID: | HEXI2_HUMAN |
| Immunogen Region: | 147-286 |
| Immunogen Sequence: | LMNDRDPEEPNLDVPHGISH PGSSGESEAGDSDGRGRAHG EFQRKDFSETYERFHTESLQ GRSKQELVRDYLELEKRLSQ AEEETRRLQQLQACTGQQSC RQVEELAAEVQRLRTENQRL RQENQMWNREGCRCDEEPGT |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 147-286 of human HEXIM2 (NP_653209.1). |
| Tissue Specificity | Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed. |
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. |
| Protein Name | Protein Hexim2Hexamethylene Bis-Acetamide-Inducible Protein 2 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Hexim2 antibodyAnti-Hexamethylene Bis-Acetamide-Inducible Protein 2 antibodyAnti-HEXIM2 antibodyAnti-L3 antibody |
Information sourced from Uniprot.org
