| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Probable E3 ubiquitin-protein ligase HERC1 (509-559 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HERC1 |
| Gene ID: |
8925 |
| Uniprot ID: |
HERC1_HUMAN |
| Immunogen Region: |
509-559 aa |
| Specificity: |
This antibody detects endogenous levels of human HERC1 |
| Immunogen: |
Synthesized peptide derived from the human HERC1 at the amino acid range 509-559 |
| Function | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
| Protein Name | Probable E3 Ubiquitin-Protein Ligase Herc1Hect Domain And Rcc1-Like Domain-Containing Protein 1Hect-Type E3 Ubiquitin Transferase Herc1P532P619 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmCytosolGolgi ApparatusRecruited Onto Actin-Rich Surface Protrusions |
| Alternative Antibody Names | Anti-Probable E3 Ubiquitin-Protein Ligase Herc1 antibodyAnti-Hect Domain And Rcc1-Like Domain-Containing Protein 1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Herc1 antibodyAnti-P532 antibodyAnti-P619 antibodyAnti-HERC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
