| Function | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
| Protein Name | Probable E3 Ubiquitin-Protein Ligase Herc1Hect Domain And Rcc1-Like Domain-Containing Protein 1Hect-Type E3 Ubiquitin Transferase Herc1P532P619 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmCytosolGolgi ApparatusRecruited Onto Actin-Rich Surface Protrusions |
| Alternative Antibody Names | Anti-Probable E3 Ubiquitin-Protein Ligase Herc1 antibodyAnti-Hect Domain And Rcc1-Like Domain-Containing Protein 1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Herc1 antibodyAnti-P532 antibodyAnti-P619 antibodyAnti-HERC1 antibody |
Information sourced from Uniprot.org
