| Function | Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA). Possesses both DNA unwinding and annealing activities. Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA. Efficiently unwinds substrates containing 3' overhangs or a D-loop. In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing. Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences. |
| Protein Name | Helicase Polq-LikeMus308-Like HelicasePolq-Like Helicase |
| Cellular Localisation | NucleusChromosomeLocalizes To Sites Of Dna DamageLocalizes To Damaged Replication Forks |
| Alternative Antibody Names | Anti-Helicase Polq-Like antibodyAnti-Mus308-Like Helicase antibodyAnti-Polq-Like Helicase antibodyAnti-HELQ antibodyAnti-HEL308 antibody |
Information sourced from Uniprot.org
