| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase HECW2 (481-530) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HECW2 |
| Gene ID: | 57520 |
| Uniprot ID: | HECW2_HUMAN |
| Immunogen Region: | 481-530 |
| Specificity: | NEDL2 Polyclonal Antibody detects endogenous levels of NEDL2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human HECW2. AA range:481-530 |
| Tissue Specificity | Predominantly expressed in adult brain, lung and heart. |
| Post Translational Modifications | Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hecw2Hect - C2 And Ww Domain-Containing Protein 2Hect-Type E3 Ubiquitin Transferase Hecw2Nedd4-Like E3 Ubiquitin-Protein Ligase 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonSpindle |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hecw2 antibodyAnti-Hect - C2 And Ww Domain-Containing Protein 2 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Hecw2 antibodyAnti-Nedd4-Like E3 Ubiquitin-Protein Ligase 2 antibodyAnti-HECW2 antibodyAnti-KIAA1301 antibodyAnti-NEDL2 antibody |
Information sourced from Uniprot.org