| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase HECW2 (481-530) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HECW2 |
| Gene ID: |
57520 |
| Uniprot ID: |
HECW2_HUMAN |
| Immunogen Region: |
481-530 |
| Specificity: |
NEDL2 Polyclonal Antibody detects endogenous levels of NEDL2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human HECW2. AA range:481-530 |
| Tissue Specificity | Predominantly expressed in adult brain, lung and heart. |
| Post Translational Modifications | Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hecw2Hect - C2 And Ww Domain-Containing Protein 2Hect-Type E3 Ubiquitin Transferase Hecw2Nedd4-Like E3 Ubiquitin-Protein Ligase 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonSpindle |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hecw2 antibodyAnti-Hect - C2 And Ww Domain-Containing Protein 2 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Hecw2 antibodyAnti-Nedd4-Like E3 Ubiquitin-Protein Ligase 2 antibodyAnti-HECW2 antibodyAnti-KIAA1301 antibodyAnti-NEDL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
