Anti-HECW2 antibody (481-530) (STJ94392)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human HECW2. AA range:481-530
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase HECW2 (481-530) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HECW2 |
| Gene ID | 57520 |
| Uniprot ID | HECW2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HECW2. AA range:481-530 |
| Immunogen Region | 481-530 |
| Specificity | NEDL2 Polyclonal Antibody detects endogenous levels of NEDL2 protein. |
Additional Info
| Tissue Specificity | Predominantly expressed in adult brain, lung and heart. |
| Post Translational Modifications | Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hecw2Hect - C2 And Ww Domain-Containing Protein 2Hect-Type E3 Ubiquitin Transferase Hecw2Nedd4-Like E3 Ubiquitin-Protein Ligase 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonSpindle |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hecw2 antibodyAnti-Hect - C2 And Ww Domain-Containing Protein 2 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Hecw2 antibodyAnti-Nedd4-Like E3 Ubiquitin-Protein Ligase 2 antibodyAnti-HECW2 antibodyAnti-KIAA1301 antibodyAnti-NEDL2 antibody |
Information sourced from Uniprot.org