| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HECTD1 (2518-2610) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HECTD1 |
| Gene ID: |
25831 |
| Uniprot ID: |
HECD1_HUMAN |
| Immunogen Region: |
2518-2610 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 2518-2610 of human HECTD1 (NP_056197.3). |
| Immunogen Sequence: |
PGFLRFVRVLCGMSSDERKA FLQFTTGCSTLPPGGLANLH PRLTVVRKVDATDASYPSVN TCVHYLKLPEYSSEEIMRER LLAATMEKGFHLN |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure. Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hectd1E3 Ligase For Inhibin ReceptorEulirHect Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hectd1 antibodyAnti-E3 Ligase For Inhibin Receptor antibodyAnti-Eulir antibodyAnti-Hect Domain-Containing Protein 1 antibodyAnti-HECTD1 antibodyAnti-KIAA1131 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
