| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HDGF |
| Gene ID: | 3068 |
| Uniprot ID: | HDGF_HUMAN |
| Immunogen Region: | 1-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HDGF (NP_004485.1). |
| Immunogen Sequence: | MSRSNRQKEYKCGDLVFAKM KGYPHWPARIDEMPEAAVKS TANKYQVFFFGTHETAFLGP KDLFPYEESKEKFGKPNKRK GFSEGLWEIENNPTVKASGY QSSQKKSCVEEPEPEPEAAE GDGDKKGNAEGSSDEEGKLV IDEPAKEKNEKGALKRRAGD LLEDSPKRPKEAENPEGEEK EAATLEVERPLPMEVEKNST PSEPGSGRGPPQEEEEEEDE EEEATKEDAEAPGIRDHES |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Sumoylated with SUMO1. Sumoylation prevents binding to chromatin. Phosphorylation at Ser-165 is likely to be required for secretion. |
| Function | Isoform 1: Acts as a transcriptional repressor. Has mitogenic activity for fibroblasts. Heparin-binding protein. Isoform 2: Does not have mitogenic activity for fibroblasts. Does not bind heparin. Isoform 3: Has mitogenic activity for fibroblasts. Heparin-binding protein. |
| Protein Name | Hepatoma-Derived Growth FactorHdgfHigh Mobility Group Protein 1-Like 2Hmg-1l2 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Isoform 1: NucleusCytoplasmSecretedExtracellular ExosomeSecreted By Exosomes And Is Located Inside The ExosomeMay Also Be Secreted As Free Protein Via An As Yet Unknown PathwayIsoform 2: NucleusSecreted By Exosomes And Is Located On The Outer Exosome SurfaceIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Hepatoma-Derived Growth Factor antibodyAnti-Hdgf antibodyAnti-High Mobility Group Protein 1-Like 2 antibodyAnti-Hmg-1l2 antibodyAnti-HDGF antibodyAnti-HMG1L2 antibody |
Information sourced from Uniprot.org
![Anti-HDGF antibody [SM5124] (STJA0005124)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/180177/403610/STJA0005124_1__33554.1738950620.png?c=1 "Anti-HDGF antibody [SM5124] (STJA0005124)")
