| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/IP |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HDAC6 (836-1104) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IHC-P 1:100-1:500IF/ICC 1:50-1:200IP 1:20-1:50 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HDAC6 |
| Gene ID: |
10013 |
| Uniprot ID: |
HDAC6_HUMAN |
| Immunogen Region: |
836-1104 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 836-1104 of human HDAC6 (NP_006035.2). |
| Immunogen Sequence: |
VMKVEDREGPSSSKLVTKKA PQPAKPRLAERMTTREKKVL EAGMGKVTSASFGEESTPGQ TNSETAVVALTQDQPSEAAT GGATLAQTISEAAIGGAMLG QTTSEEAVGGATPDQTTSEE TVGGAILDQTTSEDAVGGAT LGQTTSEEAVGGATLAQTTS EAAMEGATLDQTTSEEAPGG TELIQTPLASSTDHQTPPTS PVQGTTPQISPSTLIGSLRT LELGSESQGASESQAPGEE |
| Post Translational Modifications | Phosphorylated by AURKA.phosphorylation increases HDAC6-mediated deacetylation of alpha-tubulin and subsequent disassembly of cilia. Ubiquitinated. Its polyubiquitination however does not lead to its degradation. Sumoylated in vitro. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly.via deacetylation of alpha-tubulin. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. |
| Protein Name | Histone Deacetylase 6Hd6Tubulin-Lysine Deacetylase Hdac6 |
| Database Links | Reactome: R-HSA-2122947Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3371511Reactome: R-HSA-350054Reactome: R-HSA-5617833Reactome: R-HSA-8878166Reactome: R-HSA-8940973Reactome: R-HSA-9613829Reactome: R-HSA-9615710Reactome: R-HSA-9646399 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusPerikaryonCell ProjectionDendriteAxonCiliumMicrotubule Organizing CenterCentrosomeCilium Basal BodyIt Is Mainly CytoplasmicWhere It Is Associated With Microtubules |
| Alternative Antibody Names | Anti-Histone Deacetylase 6 antibodyAnti-Hd6 antibodyAnti-Tubulin-Lysine Deacetylase Hdac6 antibodyAnti-HDAC6 antibodyAnti-KIAA0901 antibodyAnti-JM21 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
