Anti-HCN2 antibody (60-110 aa) (STJ13101198)

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STJ13101198-100

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Host: Rabbit
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-HCN2 (60-110 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: HCN2
Gene ID: 610
Uniprot ID: HCN2_HUMAN
Immunogen Region: 60-110 aa
Specificity: Specific for HCN2.
Immunogen: A synthetic peptide from aa region 60-110 of human HCN2 conjugated to blue carrier protein was used as the antigen.
Post Translational Modifications Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. S-palmitoylated. N-glycosylated.required for cell surface trafficking of HCN2.
Function Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Involved in the initiation of neuropathic pain in sensory neurons.
Protein Name Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2
Brain Cyclic Nucleotide-Gated Channel 2
Bcng-2
Database Links Reactome: R-HSA-1296061
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 antibody
Anti-Brain Cyclic Nucleotide-Gated Channel 2 antibody
Anti-Bcng-2 antibody
Anti-HCN2 antibody
Anti-BCNG2 antibody

Information sourced from Uniprot.org