| Short Description : | Rabbit polyclonal anti-HCN2 (60-110 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/WB |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation: | Lyophilised |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | HCN2 |
| Gene ID: | 610 |
| Uniprot ID: | HCN2_HUMAN |
| Immunogen: | A synthetic peptide from aa region 60-110 of human HCN2 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region: | 60-110 aa |
| Specificity: | Specific for HCN2. |
| Post Translational Modifications | Phosphorylation at Ser-668 by PRKG2 shifts the voltage-dependence to more negative voltages, hence counteracting the stimulatory effect of cGMP on gating. S-palmitoylated. N-glycosylated.required for cell surface trafficking of HCN2. |
| Function | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Involved in the initiation of neuropathic pain in sensory neurons. |
| Protein Name | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2Brain Cyclic Nucleotide-Gated Channel 2Bcng-2 |
| Database Links | Reactome: R-HSA-1296061 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Brain Cyclic Nucleotide-Gated Channel 2 antibodyAnti-Bcng-2 antibodyAnti-HCN2 antibodyAnti-BCNG2 antibody |
Information sourced from Uniprot.org
