| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HCAR1 |
| Gene ID: | 27198 |
| Uniprot ID: | HCAR1_HUMAN |
| Immunogen Region: | 250-346 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-346 of human HCAR1 (NP_115943.1). |
| Immunogen Sequence: | SACDPSVHGALHITLSFTYM NSMLDPLVYYFSSPSFPKFY NKLKICSLKPKQPGHSKTQR PEEMPISNLGRRSCISVANS FQSQSDGQWDPHIVEWH |
| Tissue Specificity | Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus. |
| Function | Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway. |
| Protein Name | Hydroxycarboxylic Acid Receptor 1G-Protein Coupled Receptor 104G-Protein Coupled Receptor 81 |
| Database Links | Reactome: R-HSA-3296197Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Hydroxycarboxylic Acid Receptor 1 antibodyAnti-G-Protein Coupled Receptor 104 antibodyAnti-G-Protein Coupled Receptor 81 antibodyAnti-HCAR1 antibodyAnti-GPR104 antibodyAnti-GPR81 antibodyAnti-HCA1 antibodyAnti-FKSG80 antibody |
Information sourced from Uniprot.org