| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-HCLS1-associated protein X-1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HAX1 |
| Gene ID: | 10456 |
| Uniprot ID: | HAX1_HUMAN |
| Specificity: | This antibody detects endogenous levels of HAX1 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human HAX1 |
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. |
| Function | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
| Protein Name | Hcls1-Associated Protein X-1 Hs1-Associating Protein X-1 Hax-1 Hs1-Binding Protein 1 Hsp1bp-1 |
| Cellular Localisation | Mitochondrion Matrix Endoplasmic Reticulum Nucleus Membrane Cytoplasmic Vesicle Cytoplasm Cell Cortex Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Sarcoplasmic Reticulum P-Body Isoform 1: Cytoplasm Nucleus Predominantly Cytoplasmic Also Detected In The Nucleus When Nuclear Export Is Inhibited And In Response To Cellular Stress Caused By Arsenite (In Vitro) Isoform 3: Cytoplasm Also Detected In The Nucleus When Nuclear Export Is Inhibited (In Vitro) Isoform 4: Cytoplasm Shuttles Between Nucleus And Cytoplasm Isoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Hcls1-Associated Protein X-1 antibody Anti-Hs1-Associating Protein X-1 antibody Anti-Hax-1 antibody Anti-Hs1-Binding Protein 1 antibody Anti-Hsp1bp-1 antibody Anti-HAX1 antibody Anti-HS1BP1 antibody |
Information sourced from Uniprot.org