| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HCLS1-associated protein X-1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HAX1 |
| Gene ID: |
10456 |
| Uniprot ID: |
HAX1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of HAX1 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human HAX1 |
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. |
| Function | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
| Protein Name | Hcls1-Associated Protein X-1Hs1-Associating Protein X-1Hax-1Hs1-Binding Protein 1Hsp1bp-1 |
| Cellular Localisation | Mitochondrion MatrixEndoplasmic ReticulumNucleus MembraneCytoplasmic VesicleCytoplasmCell CortexCell MembranePeripheral Membrane ProteinCytoplasmic SideSarcoplasmic ReticulumP-BodyIsoform 1: CytoplasmNucleusPredominantly CytoplasmicAlso Detected In The Nucleus When Nuclear Export Is InhibitedAnd In Response To Cellular Stress Caused By Arsenite (In Vitro)Isoform 3: CytoplasmAlso Detected In The Nucleus When Nuclear Export Is Inhibited (In Vitro)Isoform 4: CytoplasmShuttles Between Nucleus And CytoplasmIsoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Hcls1-Associated Protein X-1 antibodyAnti-Hs1-Associating Protein X-1 antibodyAnti-Hax-1 antibodyAnti-Hs1-Binding Protein 1 antibodyAnti-Hsp1bp-1 antibodyAnti-HAX1 antibodyAnti-HS1BP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
