| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HADHB |
| Gene ID: | 3032 |
| Uniprot ID: | ECHB_HUMAN |
| Immunogen Region: | 34-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-270 of human HADHB (NP_000174.1). |
| Immunogen Sequence: | AAPAVQTKTKKTLAKPNIRN VVVVDGVRTPFLLSGTSYKD LMPHDLARAALTGLLHRTSV PKEVVDYIIFGTVIQEVKTS NVAREAALGAGFSDKTPAHT VTMACISANQAMTTGVGLIA SGQCDVIVAGGVELMSDVPI RHSRKMRKLMLDLNKAKSMG QRLSLISKFRFNFLAPELPA VSEFSTSETMGHSADRLAAA FAVSRLEQDEYALRSHSLAK KAQDEGLLSDVVPFKVP |
| Function | Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity. |
| Protein Name | Trifunctional Enzyme Subunit Beta - MitochondrialTp-Beta Includes - 3-Ketoacyl-Coa ThiolaseAcetyl-Coa AcyltransferaseBeta-Ketothiolase |
| Database Links | Reactome: R-HSA-1482798Reactome: R-HSA-77285Reactome: R-HSA-77288Reactome: R-HSA-77305Reactome: R-HSA-77310Reactome: R-HSA-77346Reactome: R-HSA-77348Reactome: R-HSA-77350 |
| Cellular Localisation | MitochondrionMitochondrion Inner MembraneMitochondrion Outer MembraneEndoplasmic ReticulumProtein Stability And Association With Membranes Require Hadha |
| Alternative Antibody Names | Anti-Trifunctional Enzyme Subunit Beta - Mitochondrial antibodyAnti-Tp-Beta Includes - 3-Ketoacyl-Coa Thiolase antibodyAnti-Acetyl-Coa Acyltransferase antibodyAnti-Beta-Ketothiolase antibodyAnti-HADHB antibodyAnti-MSTP029 antibody |
Information sourced from Uniprot.org
