| Tissue Specificity | Widely expressed. |
| Function | Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids. Plays a significant role in the biosynthesis of heptadecanal in the liver. |
| Protein Name | 2-Hydroxyacyl-Coa Lyase 12-Hydroxyphytanoyl-Coa Lyase2-HpclPhytanoyl-Coa 2-Hydroxylase 2 |
| Database Links | Reactome: R-HSA-389599Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome |
| Alternative Antibody Names | Anti-2-Hydroxyacyl-Coa Lyase 1 antibodyAnti-2-Hydroxyphytanoyl-Coa Lyase antibodyAnti-2-Hpcl antibodyAnti-Phytanoyl-Coa 2-Hydroxylase 2 antibodyAnti-HACL1 antibodyAnti-HPCL antibodyAnti-HPCL2 antibodyAnti-PHYH2 antibodyAnti-HSPC279 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and CAT1 knockdown (KD) HeLa cells using [KD Validated] CAT1 Rabbit pAb (STJ11107042) at1:1000 dilution. <br>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br>Lysates/proteins: 17 Mu g per lane. <br>Blocking buffer: 3% nonfat dry milk in TBST. <br>Detection: ECL Basic Kit <br>Exposure time: 20s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/186238/407927/STJ11107042_1__86808.1744894391.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and CAT1 knockdown (KD) HeLa cells using [KD Validated] CAT1 Rabbit pAb (STJ11107042) at1:1000 dilution. <br>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br>Lysates/proteins: 17 Mu g per lane. <br>Blocking buffer: 3% nonfat dry milk in TBST. <br>Detection: ECL Basic Kit <br>Exposure time: 20s.")