| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HABP2 (24-313) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HABP2 |
| Gene ID: |
3026 |
| Uniprot ID: |
HABP2_HUMAN |
| Immunogen Region: |
24-313 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-313 of human HABP2 (NP_004123.1). |
| Immunogen Sequence: |
FSLMSLLESLDPDWTPDQYD YSYEDYNQEENTSSTLTHAE NPDWYYTEDQADPCQPNPCE HGGDCLVHGSTFTCSCLAPF SGNKCQKVQNTCKDNPCGRG QCLITQSPPYYRCVCKHPYT GPSCSQVVPVCRPNPCQNGA TCSRHKRRSKFTCACPDQFK GKFCEIGSDDCYVGDGYSYR GKMNRTVNQHACLYWNSHLL LQENYNMFMEDAETHGIGEH NFCRNPDADEKPWCFIKVT |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments. |
| Function | Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration. |
| Protein Name | Hyaluronan-Binding Protein 2Factor Vii-Activating ProteaseFactor Seven-Activating ProteaseFsapHepatocyte Growth Factor Activator-Like ProteinPlasma Hyaluronan-Binding Protein Cleaved Into - Hyaluronan-Binding Protein 2 50 Kda Heavy Chain - Hyaluronan-Binding Protein 2 50 Kda Heavy Chain Alternate Form - Hyaluronan-Binding Protein 2 27 Kda Light Chain - Hyaluronan-Binding Protein 2 27 Kda Light Chain Alternate Form |
| Cellular Localisation | SecretedSecreted As An Inactive Single-Chain Precursor And Is Then Activated To A Heterodimeric Form |
| Alternative Antibody Names | Anti-Hyaluronan-Binding Protein 2 antibodyAnti-Factor Vii-Activating Protease antibodyAnti-Factor Seven-Activating Protease antibodyAnti-Fsap antibodyAnti-Hepatocyte Growth Factor Activator-Like Protein antibodyAnti-Plasma Hyaluronan-Binding Protein Cleaved Into - Hyaluronan-Binding Protein 2 50 Kda Heavy Chain - Hyaluronan-Binding Protein 2 50 Kda Heavy Chain Alternate Form - Hyaluronan-Binding Protein 2 27 Kda Light Chain - Hyaluronan-Binding Protein 2 27 Kda Light Chain Alternate Form antibodyAnti-HABP2 antibodyAnti-HGFAL antibodyAnti-PHBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
