| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HABP2 |
| Gene ID: | 3026 |
| Uniprot ID: | HABP2_HUMAN |
| Immunogen Region: | 24-313 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-313 of human HABP2 (NP_004123.1). |
| Immunogen Sequence: | FSLMSLLESLDPDWTPDQYD YSYEDYNQEENTSSTLTHAE NPDWYYTEDQADPCQPNPCE HGGDCLVHGSTFTCSCLAPF SGNKCQKVQNTCKDNPCGRG QCLITQSPPYYRCVCKHPYT GPSCSQVVPVCRPNPCQNGA TCSRHKRRSKFTCACPDQFK GKFCEIGSDDCYVGDGYSYR GKMNRTVNQHACLYWNSHLL LQENYNMFMEDAETHGIGEH NFCRNPDADEKPWCFIKVT |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments. |
| Function | Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration. |
| Protein Name | Hyaluronan-Binding Protein 2 Factor Vii-Activating Protease Factor Seven-Activating Protease Fsap Hepatocyte Growth Factor Activator-Like Protein Plasma Hyaluronan-Binding Protein Cleaved Into - Hyaluronan-Binding Protein 2 50 Kda Heavy Chain - Hyaluronan-Binding Protein 2 50 Kda Heavy Chain Alternate Form - Hyaluronan-Binding Protein 2 27 Kda Light Chain - Hyaluronan-Binding Protein 2 27 Kda Light Chain Alternate Form |
| Cellular Localisation | Secreted Secreted As An Inactive Single-Chain Precursor And Is Then Activated To A Heterodimeric Form |
| Alternative Antibody Names | Anti-Hyaluronan-Binding Protein 2 antibody Anti-Factor Vii-Activating Protease antibody Anti-Factor Seven-Activating Protease antibody Anti-Fsap antibody Anti-Hepatocyte Growth Factor Activator-Like Protein antibody Anti-Plasma Hyaluronan-Binding Protein Cleaved Into - Hyaluronan-Binding Protein 2 50 Kda Heavy Chain - Hyaluronan-Binding Protein 2 50 Kda Heavy Chain Alternate Form - Hyaluronan-Binding Protein 2 27 Kda Light Chain - Hyaluronan-Binding Protein 2 27 Kda Light Chain Alternate Form antibody Anti-HABP2 antibody Anti-HGFAL antibody Anti-PHBP antibody |
Information sourced from Uniprot.org