| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GUCY2C (24-330) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GUCY2C |
| Gene ID: |
2984 |
| Uniprot ID: |
GUC2C_HUMAN |
| Immunogen Region: |
24-330 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-330 of human GUCY2C (NP_004954.2). |
| Immunogen Sequence: |
SQVSQNCHNGSYEISVLMMG NSAFAEPLKNLEDAVNEGLE IVRGRLQNAGLNVTVNATFM YSDGLIHNSGDCRSSTCEGL DLLRKISNAQRMGCVLIGPS CTYSTFQMYLDTELSYPMIS AGSFGLSCDYKETLTRLMSP ARKLMYFLVNFWKTNDLPFK TYSWSTSYVYKNGTETEDCF WYLNALEASVSYFSHELGFK VVLRQDKEFQDILMDHNRKS NVIIMCGGPEFLYKLKGDR |
| Post Translational Modifications | Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GUCY2C activation. |
| Function | Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin. |
| Protein Name | Guanylyl Cyclase CGc-CHeat-Stable Enterotoxin ReceptorSta ReceptorHstarIntestinal Guanylate Cyclase |
| Database Links | Reactome: R-HSA-8935690Reactome: R-HSA-8942233 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneThe 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose ResiduesWhile A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form |
| Alternative Antibody Names | Anti-Guanylyl Cyclase C antibodyAnti-Gc-C antibodyAnti-Heat-Stable Enterotoxin Receptor antibodyAnti-Sta Receptor antibodyAnti-Hstar antibodyAnti-Intestinal Guanylate Cyclase antibodyAnti-GUCY2C antibodyAnti-GUC2C antibodyAnti-STAR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
