| Host: | Mouse |
| Applications: | WB/IP/ICC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-General transcription factor IIH subunit 1 is suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 3E8-D3-H8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:300ICC 1:50 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GTF2H1 |
| Gene ID: | 2965 |
| Uniprot ID: | TF2H1_HUMAN |
| Specificity: | This antibody detects endogenous levels of GTF2H1 and does not cross-react with related proteins. |
| Immunogen: | Purified recombinant human GTF2H1protein fragments expressed in E.coli. |
| Function | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. |
| Protein Name | General Transcription Factor Iih Subunit 1Basic Transcription Factor 2 62 Kda SubunitBtf2 P62General Transcription Factor Iih Polypeptide 1Tfiih Basal Transcription Factor Complex P62 Subunit |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167160Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-167200Reactome: R-HSA-167246Reactome: R-HSA-427413Reactome: R-HSA-5696395Reactome: R-HSA-5696400Reactome: R-HSA-674695Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-6796648Reactome: R-HSA-72086Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-73863Reactome: R-HSA-75953Reactome: R-HSA-75955Reactome: R-HSA-76042Reactome: R-HSA-77075 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-General Transcription Factor Iih Subunit 1 antibodyAnti-Basic Transcription Factor 2 62 Kda Subunit antibodyAnti-Btf2 P62 antibodyAnti-General Transcription Factor Iih Polypeptide 1 antibodyAnti-Tfiih Basal Transcription Factor Complex P62 Subunit antibodyAnti-GTF2H1 antibodyAnti-BTF2 antibody |
Information sourced from Uniprot.org
