| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GTF2F1 |
| Gene ID: | 2962 |
| Uniprot ID: | T2FA_HUMAN |
| Immunogen Region: | 390-517 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 390-517 of GTF2F1 (NP_002087.2). |
| Immunogen Sequence: | PSAEGGSTSSTLRAAASKLE QGKRVSEMPAAKRLRLDTGP QSLSGKSTPQPPSGKTTPNS GDVQVTEDAVRRYLTRKPMT TKDLLKKFQTKKTGLSSEQT VNVLAQILKRLNPERKMIND KMHFSLKE |
| Post Translational Modifications | Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases. |
| Function | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. |
| Protein Name | General Transcription Factor Iif Subunit 1General Transcription Factor Iif 74 Kda SubunitTranscription Initiation Factor Iif Subunit AlphaTfiif-AlphaTranscription Initiation Factor Rap74 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167160Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-167200Reactome: R-HSA-167238Reactome: R-HSA-167242Reactome: R-HSA-167243Reactome: R-HSA-167246Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-168325Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-6803529Reactome: R-HSA-6807505Reactome: R-HSA-72086Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-72203Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-75953Reactome: R-HSA-75955Reactome: R-HSA-76042Reactome: R-HSA-77075Reactome: R-HSA-8851708Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-General Transcription Factor Iif Subunit 1 antibodyAnti-General Transcription Factor Iif 74 Kda Subunit antibodyAnti-Transcription Initiation Factor Iif Subunit Alpha antibodyAnti-Tfiif-Alpha antibodyAnti-Transcription Initiation Factor Rap74 antibodyAnti-GTF2F1 antibodyAnti-RAP74 antibody |
Information sourced from Uniprot.org
