| Tissue Specificity | Highly expressed in IUCC stage II colorectal cancer (CRC). |
| Function | GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA. GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. |
| Protein Name | Eukaryotic Peptide Chain Release Factor Gtp-Binding Subunit Erf3bEukaryotic Peptide Chain Release Factor Subunit 3bErf3bG1 To S Phase Transition Protein 2 Homolog |
| Database Links | Reactome: R-HSA-72764Reactome: R-HSA-9010553Reactome: R-HSA-975956Reactome: R-HSA-975957 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Eukaryotic Peptide Chain Release Factor Gtp-Binding Subunit Erf3b antibodyAnti-Eukaryotic Peptide Chain Release Factor Subunit 3b antibodyAnti-Erf3b antibodyAnti-G1 To S Phase Transition Protein 2 Homolog antibodyAnti-GSPT2 antibodyAnti-ERF3B antibody |
Information sourced from Uniprot.org
