Anti-GSPT2 antibody (1-190 aa) (STJ11105982)

SKU:
STJ11105982
€140.63 - €655.63
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: GSPT2
Gene ID: 23708
Uniprot ID: ERF3B_HUMAN
Immunogen Region: 1-190 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human GSPT2 (NP_060564.2).
Immunogen Sequence: MDSGSSSSDSAPDCWDQVDM ESPGSAPSGDGVSSAVAEAQ REPLSSAFSRKLNVNAKPFV PNVHAAEFVPSFLRGPTQPP TLPAGSGSNDETCTGAGYPQ GKRMGRGAPVEPSREEPLVS LEGSNSAVTMELSEPVVENG EVEMALEESWEHSKEVSEAE PGGGSSGDSGPPEESGQEMM EEKEEIRKSK
Tissue Specificity Highly expressed in IUCC stage II colorectal cancer (CRC).
Function GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA. GSPT2/ERF3B mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. GTP hydrolysis by GSPT2/ERF3B induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Protein Name Eukaryotic Peptide Chain Release Factor Gtp-Binding Subunit Erf3b
Eukaryotic Peptide Chain Release Factor Subunit 3b
Erf3b
G1 To S Phase Transition Protein 2 Homolog
Database Links Reactome: R-HSA-72764
Reactome: R-HSA-9010553
Reactome: R-HSA-975956
Reactome: R-HSA-975957
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Eukaryotic Peptide Chain Release Factor Gtp-Binding Subunit Erf3b antibody
Anti-Eukaryotic Peptide Chain Release Factor Subunit 3b antibody
Anti-Erf3b antibody
Anti-G1 To S Phase Transition Protein 2 Homolog antibody
Anti-GSPT2 antibody
Anti-ERF3B antibody

Information sourced from Uniprot.org