| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GSN |
| Gene ID: | 2934 |
| Uniprot ID: | GELS_HUMAN |
| Immunogen Region: | 282-438 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 282-438 of human Gelsolin (NP_000168.1). |
| Immunogen Sequence: | AGTEDTAKEDAANRKLAKLY KVSNGAGTMSVSLVADENPF AQGALKSEDCFILDHGKDGK IFVWKGKQANTEERKAALKT ASDFITKMDYPKQTQVSVLP EGGETPLFKQFFKNWRDPDQ TDGLGLSYLSSHIANVERVP FDAATLHTSTAMAAQHG |
| Tissue Specificity | Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells. |
| Post Translational Modifications | Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids. |
| Function | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. |
| Protein Name | Gelsolin Agel Actin-Depolymerizing Factor Adf Brevin |
| Database Links | Reactome: R-HSA-264870 Reactome: R-HSA-6798695 Reactome: R-HSA-9662361 Reactome: R-HSA-977225 |
| Cellular Localisation | Isoform 2: Cytoplasm Cytoskeleton Isoform 1: Secreted |
| Alternative Antibody Names | Anti-Gelsolin antibody Anti-Agel antibody Anti-Actin-Depolymerizing Factor antibody Anti-Adf antibody Anti-Brevin antibody Anti-GSN antibody |
Information sourced from Uniprot.org