| Tissue Specificity | Widely distributed in neuronal cells of the central nervous system. |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. |
| Protein Name | Metabotropic Glutamate Receptor 5Mglur5 |
| Database Links | Reactome: R-RNO-416476Reactome: -RNO-420499Reactome: -RNO-6794361 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 5 antibodyAnti-Mglur5 antibodyAnti-Grm5 antibodyAnti-Gprc1e antibodyAnti-Mglur5 antibody |
Information sourced from Uniprot.org