| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Mouse/Rat/Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-mGluR5/1A (C-Term) for use in WB and IHC in Mouse, Rat and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: | This antibody was antigen affinity purified from serum. |
| Dilution Range: | WB 1:1000IHC 1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Grm5 |
| Gene ID: | 24418 |
| Uniprot ID: | GRM5_RAT |
| Immunogen Region: | C-Term |
| Immunogen: | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH. |
| Tissue Specificity | Widely distributed in neuronal cells of the central nervous system. |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. |
| Protein Name | Metabotropic Glutamate Receptor 5Mglur5 |
| Database Links | Reactome: R-RNO-416476Reactome: -RNO-420499Reactome: -RNO-6794361 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 5 antibodyAnti-Mglur5 antibodyAnti-Grm5 antibodyAnti-Gprc1e antibodyAnti-Mglur5 antibody |
Information sourced from Uniprot.org
