Western blot of 10 µg of HEK 293 cells expressing: 1) mGluR5 and 2) mGluR1a showing the specific immunolabeling of the ~125 kDa monomer and the ~250 kDa dimers of both mGluR1a (2) and mGluR5 (1).

Anti-GRM5 antibody (C-Term) (STJA0003688)

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STJA0003688-100
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Host: Rabbit
Applications: WB/IHC
Reactivity: Mouse/Rat/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-mGluR5/1A (C-Term) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from serum.
Dilution Range: WB 1:1000
IHC 1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Grm5
Gene ID: 24418
Uniprot ID: GRM5_RAT
Immunogen Region: C-Term
Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
Tissue Specificity Widely distributed in neuronal cells of the central nervous system.
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Protein Name Metabotropic Glutamate Receptor 5
Mglur5
Database Links Reactome: R-RNO-416476
Reactome: -RNO-420499
Reactome: -RNO-6794361
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Metabotropic Glutamate Receptor 5 antibody
Anti-Mglur5 antibody
Anti-Grm5 antibody
Anti-Gprc1e antibody
Anti-Mglur5 antibody

Information sourced from Uniprot.org

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