Anti-GRM2 nanobody [SAA1127] (STJN000270)

Anti-GRM2 nanobody [SAA1127] (STJN000270)

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STJN000270
£195.50 - £1,319.50
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Covered by St John's Laboratory Guarantee

Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Metabotropic Glutamate Receptor 2 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1127
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: GRM2
Gene ID: 2912
Uniprot ID: GRM2_HUMAN
Function Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. (Microbial infection) Plays an important role in influenza virus internalization. (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of GRM2 to enter cells. (Microbial infection) Acts as a host entry factor for SARS-CoV-2 that hijacks the endocytosis of GRM2 to enter cells.
Protein Name Metabotropic Glutamate Receptor 2
Mglur2
Database Links Reactome: R-HSA-418594
Reactome: R-HSA-420499
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Synapse
Cell Projection
Dendrite
Alternative Nanobody Names Anti-Metabotropic Glutamate Receptor 2 nanobody
Anti-Mglur2 nanobody
Anti-GRM2 nanobody
Anti-GPRC1B nanobody
Anti-MGLUR2 nanobody

Information sourced from Uniprot.org

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