| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-GRM2 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 30kDa band observed in Human Brain (Hippocampus) lysates (calculated MW of 27.5kDa according to NP_001123535.1). Recommended concentration: 1-3µg/ml.IHC: In paraffin embedd |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | GRM2 |
| Gene ID: | 2912 |
| Uniprot ID: | GRM2_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_000830.2; NP_001123535.1 |
| Specificity: | This antibody is expected to recognize both isoforms (NP_000830.2; NP_001123535.1). |
| Immunogen Sequence: | KETAPERREV |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. |
| Protein Name | Metabotropic Glutamate Receptor 2Mglur2 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSynapseCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 2 antibodyAnti-Mglur2 antibodyAnti-GRM2 antibodyAnti-GPRC1B antibodyAnti-MGLUR2 antibody |
Information sourced from Uniprot.org