Western blot of 10 µg of HEK 293 cells expressing: 1) mGluR5 and 2) mGluR1a. Specific immunolabeling of the ~125 kDa monomer and the ~250 kDa dimer of mGluR1a is shown in the second lane (2). Specificity is confirmed in the first lane (1) , as the mGluR1a antibody shows no reactivity toward mGluR5.

Anti-GRM1 antibody (C-Term) (STJA0003687)

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STJA0003687-100
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Host: Rabbit
Applications: WB/IHC
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-mGluR1A (C-Term) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from serum.
Dilution Range: WB 1:1000
IHC 1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Grm1
Gene ID: 24414
Uniprot ID: GRM1_RAT
Immunogen Region: C-Term
Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
Tissue Specificity Predominantly expressed in cerebellar Purkinje cells, CA2-CA3 pyramidal cells of the hippocampus, and mitral and tufted cells of the olfactory bulb.
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. May function in the light response in the retina. Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively.
Protein Name Metabotropic Glutamate Receptor 1
Mglur1
Database Links Reactome: R-RNO-416476
Reactome: -RNO-420499
Reactome: -RNO-6794361
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Alternative Antibody Names Anti-Metabotropic Glutamate Receptor 1 antibody
Anti-Mglur1 antibody
Anti-Grm1 antibody
Anti-Gprc1a antibody
Anti-Mglur1 antibody

Information sourced from Uniprot.org

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