• Immunohistochemistry analysis of NMDA Epsilon 3 antibody in paraffin-embedded human brain tissue.

Anti-GRIN2C antibody (937-986) (STJ94518)

SKU:
STJ94518

Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Glutamate receptor ionotropic, NMDA 2C (937-986) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GRIN2C
Gene ID: 2905
Uniprot ID: NMDE3_HUMAN
Immunogen Region: 937-986
Specificity: NMDA Epsilon 3 Polyclonal Antibody detects endogenous levels of NMDA Epsilon 3 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human NMDAepsilon3. AA range:937-986
Tissue Specificity Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
Function Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
Protein Name Glutamate Receptor Ionotropic - Nmda 2c
Glun2c
Glutamate Nmda Receptor Subunit Epsilon-3
N-Methyl D-Aspartate Receptor Subtype 2c
Nmdar2c
Nr2c
Database Links Reactome: R-HSA-438066
Reactome: R-HSA-6794361
Reactome: R-HSA-8849932
Reactome: R-HSA-9609736
Reactome: R-HSA-9617324
Reactome: R-HSA-9620244
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Alternative Antibody Names Anti-Glutamate Receptor Ionotropic - Nmda 2c antibody
Anti-Glun2c antibody
Anti-Glutamate Nmda Receptor Subunit Epsilon-3 antibody
Anti-N-Methyl D-Aspartate Receptor Subtype 2c antibody
Anti-Nmdar2c antibody
Anti-Nr2c antibody
Anti-GRIN2C antibody
Anti-NMDAR2C antibody

Information sourced from Uniprot.org