Host: | Rabbit |
Applications: | IHC/IF/ELISA |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Glutamate receptor ionotropic, NMDA 2C (937-986) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | GRIN2C |
Gene ID: | 2905 |
Uniprot ID: | NMDE3_HUMAN |
Immunogen Region: | 937-986 |
Specificity: | NMDA Epsilon 3 Polyclonal Antibody detects endogenous levels of NMDA Epsilon 3 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from human NMDAepsilon3. AA range:937-986 |
Tissue Specificity | Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas. |
Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
Protein Name | Glutamate Receptor Ionotropic - Nmda 2c Glun2c Glutamate Nmda Receptor Subunit Epsilon-3 N-Methyl D-Aspartate Receptor Subtype 2c Nmdar2c Nr2c |
Database Links | Reactome: R-HSA-438066 Reactome: R-HSA-6794361 Reactome: R-HSA-8849932 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Postsynaptic Cell Membrane |
Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 2c antibody Anti-Glun2c antibody Anti-Glutamate Nmda Receptor Subunit Epsilon-3 antibody Anti-N-Methyl D-Aspartate Receptor Subtype 2c antibody Anti-Nmdar2c antibody Anti-Nr2c antibody Anti-GRIN2C antibody Anti-NMDAR2C antibody |
Information sourced from Uniprot.org