| Host: |
Rabbit |
| Applications: |
WB/IHC/IP |
| Reactivity: |
Human/Mouse/Rabbit/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NMDAR2A (C-Term) is suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: |
This antibody was antigen affinity purified from pooled serum. |
| Dilution Range: |
WB 1:1000IHC 1:1000ICCIP 3 µl per 200 µg lysate |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Grin2a |
| Gene ID: |
24409 |
| Uniprot ID: |
NMDE1_RAT |
| Immunogen Region: |
C-Term |
| Immunogen: |
Fusion protein from the C-terminal region of the NR2A subunit. |
| Tissue Specificity | Detected in brain cortex, olfactory bulb, hippocampus including the dentate gyrus, striatum, thalamus, superior colliculus, inferior colliculus, midbrain and cerebellum (at protein level). Detected in brain cortex, hypothalamus and cerebellum. |
| Function | Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 2aGlun2aGlutamate Nmda Receptor Subunit Epsilon-1N-Methyl D-Aspartate Receptor Subtype 2aNmdar2aNr2a |
| Database Links | Reactome: R-RNO-438066Reactome: -RNO-8849932Reactome: -RNO-9609736 |
| Cellular Localisation | Cell ProjectionDendritic SpineCell MembraneMulti-Pass Membrane ProteinSynapsePostsynaptic Cell MembraneCytoplasmic Vesicle MembraneExpression At The Dendrite Cell Membrane And At Synapses Is Regulated By Sorcs2 And The Retromer Complex |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 2a antibodyAnti-Glun2a antibodyAnti-Glutamate Nmda Receptor Subunit Epsilon-1 antibodyAnti-N-Methyl D-Aspartate Receptor Subtype 2a antibodyAnti-Nmdar2a antibodyAnti-Nr2a antibodyAnti-Grin2a antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
