| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRIK2 |
| Gene ID: | 2898 |
| Uniprot ID: | GRIK2_HUMAN |
| Immunogen Region: | 30-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human GRIK2 (NP_068775.1). |
| Immunogen Sequence: | QGTTHVLRFGGIFEYVESGP MGAEELAFRFAVNTINRNRT LLPNTTLTYDTQKINLYDSF EASKKACDQLSLGVAAIFGP SHSSSANAVQSICNALGVPH IQTRWKHQVSDNKDSFYVSL YPDFSSLSRAILDLVQFFKW KTVTVVYDDSTGLIRLQELI KAPSRYNLRLKIRQLPADTK DAKPLLKEMKRGKEFHVIFD CSHEMAAGILKQALAMGMMT EYYHYIFTTLDLFALDVEP |
| Tissue Specificity | Expression is higher in cerebellum than in cerebral cortex. |
| Post Translational Modifications | Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1. Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome. Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation. |
| Function | Ionotropic glutamate receptor that functions as a cation permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2. In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses. Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons. |
| Protein Name | Glutamate Receptor Ionotropic - Kainate 2 Gluk2 Excitatory Amino Acid Receptor 4 Eaa4 Glutamate Receptor 6 Glur-6 Glur6 |
| Database Links | Reactome: R-HSA-451307 Reactome: R-HSA-451308 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Postsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Kainate 2 antibody Anti-Gluk2 antibody Anti-Excitatory Amino Acid Receptor 4 antibody Anti-Eaa4 antibody Anti-Glutamate Receptor 6 antibody Anti-Glur-6 antibody Anti-Glur6 antibody Anti-GRIK2 antibody Anti-GLUR6 antibody |
Information sourced from Uniprot.org