| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRID2 |
| Gene ID: | 2895 |
| Uniprot ID: | GRID2_HUMAN |
| Immunogen Region: | 900-1007 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 900-1007 of human GRID2 (NP_001501.2). |
| Immunogen Sequence: | IDLTPLDIDTLPTRQALEQI SDFRNTHITTTTFIPEQIQT LSRTLSAKAASGFTFGNVPE HRTGPFRHRAPNGGFFRSPI KTMSSIPYQPTPTLGLNLGN DPDRGTSI |
| Function | Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells. |
| Protein Name | Glutamate Receptor Ionotropic - Delta-2 Glud2 Glur Delta-2 Subunit |
| Cellular Localisation | Postsynaptic Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Delta-2 antibody Anti-Glud2 antibody Anti-Glur Delta-2 Subunit antibody Anti-GRID2 antibody Anti-GLURD2 antibody |
Information sourced from Uniprot.org