| Function | Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells. |
| Protein Name | Glutamate Receptor Ionotropic - Delta-2Glud2Glur Delta-2 Subunit |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Delta-2 antibodyAnti-Glud2 antibodyAnti-Glur Delta-2 Subunit antibodyAnti-GRID2 antibodyAnti-GLURD2 antibody |
Information sourced from Uniprot.org
