| Host: |
Mouse |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Glutamate receptor 3 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
1D2 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC 1:200-1:1000ELISA 1:10000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRIA3 |
| Gene ID: |
2892 |
| Uniprot ID: |
GRIA3_HUMAN |
| Specificity: |
GluR-3 Monoclonal Antibody detects endogenous levels of GluR-3 protein. |
| Immunogen: |
Purified recombinant fragment of human GluR-3 expressed in E. Coli. |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Protein Name | Glutamate Receptor 3Glur-3Ampa-Selective Glutamate Receptor 3Glur-CGlur-K3Glutamate Receptor Ionotropic - Ampa 3Glua3 |
| Database Links | Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-8849932 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneInteraction With Cnih2 And Cnih3 Promotes Cell Surface Expression |
| Alternative Antibody Names | Anti-Glutamate Receptor 3 antibodyAnti-Glur-3 antibodyAnti-Ampa-Selective Glutamate Receptor 3 antibodyAnti-Glur-C antibodyAnti-Glur-K3 antibodyAnti-Glutamate Receptor Ionotropic - Ampa 3 antibodyAnti-Glua3 antibodyAnti-GRIA3 antibodyAnti-GLUR3 antibodyAnti-GLURC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
