| Function | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. |
| Protein Name | Granzyme ACtl TryptaseCytotoxic T-Lymphocyte Proteinase 1Fragmentin-1Granzyme-1Hanukkah FactorH FactorHf |
| Database Links | |
| Cellular Localisation | Isoform Alpha: SecretedCytoplasmic GranuleDelivered Into The Target Cell By Perforin |
| Alternative Antibody Names | Anti-Granzyme A antibodyAnti-Ctl Tryptase antibodyAnti-Cytotoxic T-Lymphocyte Proteinase 1 antibodyAnti-Fragmentin-1 antibodyAnti-Granzyme-1 antibodyAnti-Hanukkah Factor antibodyAnti-H Factor antibodyAnti-Hf antibodyAnti-GZMA antibodyAnti-CTLA3 antibodyAnti-HFSP antibody |
Information sourced from Uniprot.org
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