• Western blot analysis of Human plasma, using GPVI/GP6 Rabbit polyclonal antibody (STJ11105391) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-GPVI/GP6 antibody (24-265) (STJ11105391)

SKU:
STJ11105391

£112.50 - £522.50
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GPVI/GP6 (24-265) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Gp6
Gene ID: 243816
Uniprot ID: GPVI_MOUSE
Immunogen Region: 24-265
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-265 of mouse GPVI/GP6 (NP_001156486.1).
Immunogen Sequence: GPLPKPSLQAQPSSLVPLGQ SVILRCQGPPDVDLYRLEKL KPEKYEDQDFLFIPTMERSN AGRYRCSYQNGSHWSLPSDQ LELIATGVYAKPSLSAHPSS AVPQGRDVTLKCQSPYSFDE FVLYKEGDTGSYKRPEKWYR ANFPIITVTAAHSGTYRCYS FSSSSPYLWSAPSDPLVLVV TGLSATPSQVPTEESFPVTE SSRRPSILPTNKISTTEKPM NITASPEGLSPPFGFAHQH
Tissue Specificity Megakaryocytes and platelets.
Function Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Protein Name Platelet Glycoprotein Vi
Gpvi
Glycoprotein 5
Database Links Reactome: R-MMU-114604
Reactome: -MMU-202733
Reactome: -MMU-75892
Cellular Localisation Cell Membrane
Single-Pass Membrane Protein
Alternative Antibody Names Anti-Platelet Glycoprotein Vi antibody
Anti-Gpvi antibody
Anti-Glycoprotein 5 antibody
Anti-Gp6 antibody

Information sourced from Uniprot.org

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