| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Gp6 |
| Gene ID: | 243816 |
| Uniprot ID: | GPVI_MOUSE |
| Immunogen Region: | 24-265 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-265 of mouse GPVI/GP6 (NP_001156486.1). |
| Immunogen Sequence: | GPLPKPSLQAQPSSLVPLGQ SVILRCQGPPDVDLYRLEKL KPEKYEDQDFLFIPTMERSN AGRYRCSYQNGSHWSLPSDQ LELIATGVYAKPSLSAHPSS AVPQGRDVTLKCQSPYSFDE FVLYKEGDTGSYKRPEKWYR ANFPIITVTAAHSGTYRCYS FSSSSPYLWSAPSDPLVLVV TGLSATPSQVPTEESFPVTE SSRRPSILPTNKISTTEKPM NITASPEGLSPPFGFAHQH |
| Tissue Specificity | Megakaryocytes and platelets. |
| Function | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. |
| Protein Name | Platelet Glycoprotein ViGpviGlycoprotein 5 |
| Database Links | Reactome: R-MMU-114604Reactome: -MMU-202733Reactome: -MMU-75892 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Platelet Glycoprotein Vi antibodyAnti-Gpvi antibodyAnti-Glycoprotein 5 antibodyAnti-Gp6 antibody |
Information sourced from Uniprot.org
![Anti-GP6/GPVI nanobody [SAA1026] (STJN000301)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/200914/413096/STJN000301-SDS-PAGE-1__43637.1749232598.jpg?c=1 "Anti-GP6/GPVI nanobody [SAA1026] (STJN000301)")
