| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Retinoic acid-induced protein 3 (140-189 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPRC5A |
| Gene ID: |
9052 |
| Uniprot ID: |
RAI3_HUMAN |
| Immunogen Region: |
140-189 aa |
| Specificity: |
RAI3 Polyclonal Antibody detects endogenous levels of RAI3 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human GPRC5A at the amino acid range 140-189 |
| Post Translational Modifications | Phosphorylated in two conserved double-tyrosine motifs, Tyr-317/Tyr-320 and Tyr-347/Tyr-350, by EGFR.leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. Tyr-317 and Tyr-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation. |
| Function | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. |
| Protein Name | Retinoic Acid-Induced Protein 3G-Protein Coupled Receptor Family C Group 5 Member APhorbol Ester Induced Gene 1Peig-1Retinoic Acid-Induced Gene 1 ProteinRaig-1 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneLocalized In Perinuclear VesiclesProbably Golgi-Associated Vesicles |
| Alternative Antibody Names | Anti-Retinoic Acid-Induced Protein 3 antibodyAnti-G-Protein Coupled Receptor Family C Group 5 Member A antibodyAnti-Phorbol Ester Induced Gene 1 antibodyAnti-Peig-1 antibodyAnti-Retinoic Acid-Induced Gene 1 Protein antibodyAnti-Raig-1 antibodyAnti-GPRC5A antibodyAnti-GPCR5A antibodyAnti-RAI3 antibodyAnti-RAIG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
