| Post Translational Modifications | Phosphorylated in two conserved double-tyrosine motifs, Tyr-317/Tyr-320 and Tyr-347/Tyr-350, by EGFR.leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. Tyr-317 and Tyr-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation. |
| Function | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. |
| Protein Name | Retinoic Acid-Induced Protein 3G-Protein Coupled Receptor Family C Group 5 Member APhorbol Ester Induced Gene 1Peig-1Retinoic Acid-Induced Gene 1 ProteinRaig-1 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneLocalized In Perinuclear VesiclesProbably Golgi-Associated Vesicles |
| Alternative Antibody Names | Anti-Retinoic Acid-Induced Protein 3 antibodyAnti-G-Protein Coupled Receptor Family C Group 5 Member A antibodyAnti-Phorbol Ester Induced Gene 1 antibodyAnti-Peig-1 antibodyAnti-Retinoic Acid-Induced Gene 1 Protein antibodyAnti-Raig-1 antibodyAnti-GPRC5A antibodyAnti-GPCR5A antibodyAnti-RAI3 antibodyAnti-RAIG1 antibody |
Information sourced from Uniprot.org
