• Western blot analysis of lysates from 293 and Jurkat cells, using GPR18 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HUVECcells using GPR18 antibody.
  • Immunofluorescence analysis of HUVEC cells, using GPR18 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-GPR18 antibody (191-240 aa) (STJ93370)

SKU:
STJ93370

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-N-arachidonyl glycine receptor (191-240 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GPR18
Gene ID: 2841
Uniprot ID: GPR18_HUMAN
Immunogen Region: 191-240 aa
Specificity: GPR18 Polyclonal Antibody detects endogenous levels of GPR18 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human GPR18 at the amino acid range 191-240
Function Receptor for endocannabinoid N-arachidonyl glycine (NAGly). However, conflicting results about the role of NAGly as an agonist are reported. Can also be activated by plant-derived and synthetic cannabinoid agonists. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant. Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis.
Protein Name N-Arachidonyl Glycine Receptor
Nagly Receptor
G-Protein Coupled Receptor 18
Database Links Reactome: R-HSA-373076
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle Membrane
Alternative Antibody Names Anti-N-Arachidonyl Glycine Receptor antibody
Anti-Nagly Receptor antibody
Anti-G-Protein Coupled Receptor 18 antibody
Anti-GPR18 antibody
Anti-GPCRW antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance