| Short Description : | Rabbit polyclonal anti-G-protein coupled receptor 171 (181-230 aa) for use in WB, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPR171 |
| Gene ID: | 29909 |
| Uniprot ID: | GP171_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GPR171 at the amino acid range 181-230 |
| Immunogen Region: | 181-230 aa |
| Specificity: | GPR171 Polyclonal Antibody detects endogenous levels of GPR171 protein. |
| Function | G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception. Acts as a negative regulator T cell function. |
| Protein Name | G-Protein Coupled Receptor 171G-Protein Coupled Receptor H963 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinColocalized With Gpr83 In The Paraventricular Nucleus |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 171 antibodyAnti-G-Protein Coupled Receptor H963 antibodyAnti-GPR171 antibodyAnti-H963 antibody |
Information sourced from Uniprot.org
