| Function | Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor.together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation. Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus. |
| Protein Name | Protein Gpr15lgAntimicrobial Peptide With 57 Amino Acid ResiduesAp-57Antimicrobial Peptide-57Colon-Derived Susd2 Binding FactorCsbfProtein Gpr15 LigandProtein Gpr15lSecreted Protein C10orf99 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Protein Gpr15lg antibodyAnti-Antimicrobial Peptide With 57 Amino Acid Residues antibodyAnti-Ap-57 antibodyAnti-Antimicrobial Peptide-57 antibodyAnti-Colon-Derived Susd2 Binding Factor antibodyAnti-Csbf antibodyAnti-Protein Gpr15 Ligand antibodyAnti-Protein Gpr15l antibodyAnti-Secreted Protein C10orf99 antibodyAnti-GPR15LG antibodyAnti-C10orf99 antibodyAnti-GPR15L antibodyAnti-UNQ1833 antibodyAnti-PRO3446 antibody |
Information sourced from Uniprot.org
