Anti-GP6/GPVI nanobody [SAA1026] (STJN000301)

Anti-GP6/GPVI nanobody [SAA1026] (STJN000301)

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STJN000301
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Platelet Glycoprotein Vi is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1026
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: GP6
Gene ID: 51206
Uniprot ID: GPVI_HUMAN
Post Translational Modifications N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
Function Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Protein Name Platelet Glycoprotein Vi
Gpvi
Glycoprotein 6
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-202733
Reactome: R-HSA-75892
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Membrane Protein
Isoform 2: Cell Membrane
Alternative Nanobody Names Anti-Platelet Glycoprotein Vi nanobody
Anti-Gpvi nanobody
Anti-Glycoprotein 6 nanobody
Anti-GP6 nanobody

Information sourced from Uniprot.org

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