| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Platelet glycoprotein VI (21-50 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Clone ID : | 21-50 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GP6 |
| Gene ID: | 51206 |
| Uniprot ID: | GPVI_HUMAN |
| Immunogen Region: | 21-50 aa |
| Specificity: | GPVI Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein at the amino acid 21-50 |
| Post Translational Modifications | N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX). |
| Function | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. |
| Protein Name | Platelet Glycoprotein ViGpviGlycoprotein 6 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202733Reactome: R-HSA-75892 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Membrane ProteinIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Platelet Glycoprotein Vi antibodyAnti-Gpvi antibodyAnti-Glycoprotein 6 antibodyAnti-GP6 antibody |
Information sourced from Uniprot.org
