![Anti-GP2 nanobody [SAA1240] (STJN000237)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200850/413032/STJN000237-SDS-PAGE-1__62903.1749232547.jpg?c=1 "Anti-GP2 nanobody [SAA1240] (STJN000237)")
![Anti-GP2 nanobody [SAA1240] (STJN000237)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200850/413032/STJN000237-SDS-PAGE-1__62903.1749232547.jpg?c=1 "Anti-GP2 nanobody [SAA1240] (STJN000237)")
Anti-GP2 nanobody [SAA1240] (STJN000237)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 is suitable for use in ELISA, Immunofluorescence and SPR research applications. |
| Applications | ELISA/IF/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1240 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | GP2 |
| Gene ID | 2813 |
| Uniprot ID | GP2_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH. |
| Function | Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. |
| Protein Name | Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2Pancreatic Zymogen Granule Membrane Protein Gp-2Zap75 |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-9925561 |
| Cellular Localisation | Zymogen Granule MembraneLipid-AnchorGpi-AnchorSecretedCell MembraneApical Cell MembraneMembrane RaftEndosomeAfter CleavageIn The Pancreatic Juice |
| Alternative Nanobody Names | Anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 nanobodyAnti-Pancreatic Zymogen Granule Membrane Protein Gp-2 nanobodyAnti-Zap75 nanobodyAnti-GP2 nanobody |
Information sourced from Uniprot.org