Anti-GP2 antibody (111-387) (STJ28461)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GP2 (111-387) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GP2 |
| Gene ID | 2813 |
| Uniprot ID | GP2_HUMAN |
| Immunogen Region | 111-387 |
| Immunogen Sequence | CSSILQTEERNWVSVTSPVQ ASACRNILERNQTHAIYKNT LSLVNDFIIRDTILNINFQC AYPLDMKVSLQAALQPIVSS LNVSVDGNGEFIVRMALFQD QNYTNPYEGDAVELSVESVL YVGAILEQGDTSRFNLVLRN CYATPTEDKADLVKYFIIRN SCSNQRDSTIHVEENGQSSE SRFSVQMFMFAGHYDLVFLH CEIHLCDSLNEQCQPSCSRS QVRSEVPAIDLARVLDLGP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 111-387 of human GP2 (NP_001007243.2). |
Additional Info
| Tissue Specificity | Expressed in pancreas (at protein level). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level). |
| Post Translational Modifications | N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH. |
| Function | Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. |
| Protein Name | Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2Pancreatic Zymogen Granule Membrane Protein Gp-2Zap75 |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-9925561 |
| Cellular Localisation | Zymogen Granule MembraneLipid-AnchorGpi-AnchorSecretedCell MembraneApical Cell MembraneMembrane RaftEndosomeAfter CleavageIn The Pancreatic Juice |
| Alternative Antibody Names | Anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 antibodyAnti-Pancreatic Zymogen Granule Membrane Protein Gp-2 antibodyAnti-Zap75 antibodyAnti-GP2 antibody |
Information sourced from Uniprot.org