| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GP2 |
| Gene ID: | 2813 |
| Uniprot ID: | GP2_HUMAN |
| Immunogen Region: | 111-387 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 111-387 of human GP2 (NP_001007243.2). |
| Immunogen Sequence: | CSSILQTEERNWVSVTSPVQ ASACRNILERNQTHAIYKNT LSLVNDFIIRDTILNINFQC AYPLDMKVSLQAALQPIVSS LNVSVDGNGEFIVRMALFQD QNYTNPYEGDAVELSVESVL YVGAILEQGDTSRFNLVLRN CYATPTEDKADLVKYFIIRN SCSNQRDSTIHVEENGQSSE SRFSVQMFMFAGHYDLVFLH CEIHLCDSLNEQCQPSCSRS QVRSEVPAIDLARVLDLGP |
| Tissue Specificity | Expressed in pancreas (at protein level). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level). |
| Post Translational Modifications | N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH. |
| Function | Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. |
| Protein Name | Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 Pancreatic Zymogen Granule Membrane Protein Gp-2 Zap75 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Zymogen Granule Membrane Lipid-Anchor Gpi-Anchor Secreted Cell Membrane Apical Cell Membrane Membrane Raft Endosome After Cleavage In The Pancreatic Juice |
| Alternative Antibody Names | Anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 antibody Anti-Pancreatic Zymogen Granule Membrane Protein Gp-2 antibody Anti-Zap75 antibody Anti-GP2 antibody |
Information sourced from Uniprot.org