| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GP2 (111-387) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GP2 |
| Gene ID: |
2813 |
| Uniprot ID: |
GP2_HUMAN |
| Immunogen Region: |
111-387 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 111-387 of human GP2 (NP_001007243.2). |
| Immunogen Sequence: |
CSSILQTEERNWVSVTSPVQ ASACRNILERNQTHAIYKNT LSLVNDFIIRDTILNINFQC AYPLDMKVSLQAALQPIVSS LNVSVDGNGEFIVRMALFQD QNYTNPYEGDAVELSVESVL YVGAILEQGDTSRFNLVLRN CYATPTEDKADLVKYFIIRN SCSNQRDSTIHVEENGQSSE SRFSVQMFMFAGHYDLVFLH CEIHLCDSLNEQCQPSCSRS QVRSEVPAIDLARVLDLGP |
| Tissue Specificity | Expressed in pancreas (at protein level). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level). |
| Post Translational Modifications | N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH. |
| Function | Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. |
| Protein Name | Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2Pancreatic Zymogen Granule Membrane Protein Gp-2Zap75 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Zymogen Granule MembraneLipid-AnchorGpi-AnchorSecretedCell MembraneApical Cell MembraneMembrane RaftEndosomeAfter CleavageIn The Pancreatic Juice |
| Alternative Antibody Names | Anti-Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 antibodyAnti-Pancreatic Zymogen Granule Membrane Protein Gp-2 antibodyAnti-Zap75 antibodyAnti-GP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
