| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GOPC (195-454) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GOPC |
| Gene ID: |
57120 |
| Uniprot ID: |
GOPC_HUMAN |
| Immunogen Region: |
195-454 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 195-454 of human PIST/PIST/GOPC (NP_001017408.1). |
| Immunogen Sequence: |
ARLAAKYLDKELAGRVQQIQ LLGRDMKGPAHDKLWNQLEA EIHLHRHKTVIRACRGRNDL KRPMQAPPGHDQDSLKKSQG VGPIRKVLLLKEDHEGLGIS ITGGKEHGVPILISEIHPGQ PADRCGGLHVGDAILAVNGV NLRDTKHKEAVTILSQQRGE IEFEVVYVAPEVDSDDENVE YEDESGHRYRLYLDELEGGG NPGASCKDTSGEIKVLQGFN KKAVTDTHENGDLGTASET |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes. |
| Protein Name | Golgi-Associated Pdz And Coiled-Coil Motif-Containing ProteinCftr-Associated LigandFused In GlioblastomaPdz Protein Interacting Specifically With Tc10Pist |
| Database Links | Reactome: R-HSA-5627083Reactome: R-HSA-9013406 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneSynapsePostsynaptic DensityCell ProjectionDendriteEnriched In Synaptosomal And Postsynaptic Densities (Psd) FractionsExpressed In Cell Bodies And Dendrites Of Purkinje CellsLocalized At The Trans-Golgi Network (Tgn) Of Spermatids And The Medulla Of Round Spermatides |
| Alternative Antibody Names | Anti-Golgi-Associated Pdz And Coiled-Coil Motif-Containing Protein antibodyAnti-Cftr-Associated Ligand antibodyAnti-Fused In Glioblastoma antibodyAnti-Pdz Protein Interacting Specifically With Tc10 antibodyAnti-Pist antibodyAnti-GOPC antibodyAnti-CAL antibodyAnti-FIG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
