| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-GNL3 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 65+75kDa bands observed in nuclear lysates of cell lines HeLa, HepG2 and K562 (calculated MW of 62.0kDa according to NP_055181.3). The observed 75kDa band likely represents the |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | GNL3 |
| Gene ID: | 26354 |
| Uniprot ID: | GNL3_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_055181.3; NP_996561.1 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_055181.3; NP_996561.1). Reported variants represent identical protein: NP_996561.1, NP_996562.1. |
| Immunogen Sequence: | EKNNAQSIRAIKGPH |
| Function | May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. |
| Protein Name | Guanine Nucleotide-Binding Protein-Like 3E2-Induced Gene 3 ProteinNovel Nucleolar Protein 47Nnp47Nucleolar Gtp-Binding Protein 3Nucleostemin |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusShuttles Between The Nucleus And Nucleolus |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein-Like 3 antibodyAnti-E2-Induced Gene 3 Protein antibodyAnti-Novel Nucleolar Protein 47 antibodyAnti-Nnp47 antibodyAnti-Nucleolar Gtp-Binding Protein 3 antibodyAnti-Nucleostemin antibodyAnti-GNL3 antibodyAnti-E2IG3 antibodyAnti-NS antibody |
Information sourced from Uniprot.org