Anti-GNL3 antibody (Internal) (STJ73439)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-GNL3 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 65+75kDa bands observed in nuclear lysates of cell lines HeLa, HepG2 and K562 (calculated MW of 62.0kDa according to NP_055181.3). The observed 75kDa band likely represents the |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | GNL3 |
| Gene ID | 26354 |
| Uniprot ID | GNL3_HUMAN |
| Accession Number | NP_055181.3; NP_996561.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | EKNNAQSIRAIKGPH |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_055181.3; NP_996561.1). Reported variants represent identical protein: NP_996561.1, NP_996562.1. |
Additional Info
| Function | May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. |
| Protein Name | Guanine Nucleotide-Binding Protein-Like 3E2-Induced Gene 3 ProteinNovel Nucleolar Protein 47Nnp47Nucleolar Gtp-Binding Protein 3Nucleostemin |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusShuttles Between The Nucleus And Nucleolus |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein-Like 3 antibodyAnti-E2-Induced Gene 3 Protein antibodyAnti-Novel Nucleolar Protein 47 antibodyAnti-Nnp47 antibodyAnti-Nucleolar Gtp-Binding Protein 3 antibodyAnti-Nucleostemin antibodyAnti-GNL3 antibodyAnti-E2IG3 antibodyAnti-NS antibody |
Information sourced from Uniprot.org