| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:10-1:100IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GNL3 |
| Gene ID: | 26354 |
| Uniprot ID: | GNL3_HUMAN |
| Immunogen Region: | 1-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human GNL3 (NP_996562.1). |
| Immunogen Sequence: | MTCHKRYKIQKKVREHHRKL RKEAKKRGHKKPRKDPGVPN SAPFKEALLREAELRKQRLE ELKQQQKLDRQKELEKKRKL ETNPDIKPSNVEPMEKEFGL CKTENKAKSGKQNSKKLYCQ ELKKVIEASDVVLEVLDARD PLGCRCPQVEEAIVQSGQKK LVLILNKSDLVPKENLESWL NYLKKELPTVVFRASTKPKD KGKITKRVKAKKNAAPFRSE VCFGKEGLWKLLGGFQETC |
| Tissue Specificity | Increased levels in lung tissue in cancer patients. |
| Function | May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. |
| Protein Name | Guanine Nucleotide-Binding Protein-Like 3E2-Induced Gene 3 ProteinNovel Nucleolar Protein 47Nnp47Nucleolar Gtp-Binding Protein 3Nucleostemin |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusShuttles Between The Nucleus And Nucleolus |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein-Like 3 antibodyAnti-E2-Induced Gene 3 Protein antibodyAnti-Novel Nucleolar Protein 47 antibodyAnti-Nnp47 antibodyAnti-Nucleolar Gtp-Binding Protein 3 antibodyAnti-Nucleostemin antibodyAnti-GNL3 antibodyAnti-E2IG3 antibodyAnti-NS antibody |
Information sourced from Uniprot.org