| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Guanine nucleotide-binding protein Gt subunit alpha-2 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GNAT2 |
| Gene ID: | 2780 |
| Uniprot ID: | GNAT2_HUMAN |
| Immunogen Region: | 1-50 aa |
| Specificity: | G Alpha t2 Polyclonal Antibody detects endogenous levels of G Alpha t2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GNAT2 at the amino acid range 1-50 |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. |
| Protein Name | Guanine Nucleotide-Binding Protein G(T Subunit Alpha-2Transducin Alpha-2 Chain |
| Database Links | Reactome: R-HSA-4086398Reactome: R-HSA-418594 |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentPhotoreceptor Inner SegmentLocalizes Mainly In The Outer Segment In The Dark-Adapted StateWhereas Is Translocated To The Inner Part Of The Photoreceptors In The Light-Adapted StateDuring Dark-Adapted ConditionsIn The Presence Of Unc119 Mislocalizes From The Outer Segment To The Inner Part Of Rod Photoreceptors Which Leads To Decreased Photoreceptor Damage Caused By Light |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein G(T Subunit Alpha-2 antibodyAnti-Transducin Alpha-2 Chain antibodyAnti-GNAT2 antibodyAnti-GNATC antibody |
Information sourced from Uniprot.org