| Function | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression. Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation. Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. |
| Protein Name | Cytokine-Like Nuclear Factor N-PacNpac3-Hydroxyisobutyrate Dehydrogenase-Like ProteinGlyoxylate Reductase 1 HomologNuclear Protein Np60Nuclear Protein Of 60 KdaNucleosome-Destabilizing FactorHndfPutative Oxidoreductase Glyr1 |
| Cellular Localisation | NucleusChromosomeFound In Actively Rnapolii-Transcribed Gene Bodies |
| Alternative Antibody Names | Anti-Cytokine-Like Nuclear Factor N-Pac antibodyAnti-Npac antibodyAnti-3-Hydroxyisobutyrate Dehydrogenase-Like Protein antibodyAnti-Glyoxylate Reductase 1 Homolog antibodyAnti-Nuclear Protein Np60 antibodyAnti-Nuclear Protein Of 60 Kda antibodyAnti-Nucleosome-Destabilizing Factor antibodyAnti-Hndf antibodyAnti-Putative Oxidoreductase Glyr1 antibodyAnti-GLYR1 antibodyAnti-HIBDL antibodyAnti-NDF antibodyAnti-NP60 antibodyAnti-NPAC antibody |
Information sourced from Uniprot.org
